These fish are ideal for this kind of study because their tiny embryos are transparent, making it possible to see inside the animal and watch in real time how the organs develop. We at the CSIR-Institute of Genomics and Integrative Biology, Delhi, have been studying it in the embryo of a small fish called zebrafish that is found in the waters of eastern India. The CHARGE syndrome is being studied by many scientific groups using different models. Two-thirds of the patients with CHARGE syndrome have a sporadic mutation in the gene called CHD7. The children may survive and go on to live with these deficiencies if the heart and bone defects are corrected with multiple surgeries, but those without access to such support usually do not survive past their first year.ĬHARGE syndrome is a result of defective embryonic development. CHARGE syndrome causes multiple life-threatening problems in a newborn, such as facial bone and nerve defects that cause breathing and swallowing difficulties, deafness and blindness, heart defects, genital problems and growth retardation. That would mean that there are about 50,000 patients in India as well. (CSIR-Institute of Genomics and Integrative Biology, New Delhi)ĬHARGE syndrome is a rare birth defect that affects approximately 1 in 20,000 people around the world.
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